There is some inconvenience with the high resolution interface.
For example, it's really nice to have a plus or minus button in the strategy setting, but because of that, length of the bars are reduced and it's uncomfortable to see. Also, the letters are often cut off, like stats ranking. And the letters are quite small, and growing the size of the letters in the setting increases the number of times the letters are cut off.
Overall, it feels somewhat awkward with a high resolution interface. Of course this isn't a big disruption to play, and the game remains great. It would be amazing if these things improved in the next version.