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In OOTP, there can be no empty slots in the lineup at any time. Also, when a player is injured, his slot becomes vacant immediately, and will be filled immediately, usually with a player suitable for playing the same position.
This seems to be something that is fundamental to the programming and so far can't be changed. So from time to time you will get some substitutions that don't make a lot of sense as far as efficient use of the roster is concerned.
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