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St. Louis' Lorenzo Cain connected for a two-out, two-run single off Springfield's Tommy Hunter in the bottom of the 12th inning to lift the River Walkers to a 5-4 win at Busch Stadium.
St. Louis took a 2-1 lead into the top of the ninth only to have a pinch-hit homer from Tony Kemp off Keone Kela tie it.
A Mookie Betts single in the top of the 11th inning off Jake Diekman scored Gorkys Hernandez, putting the Prairie Fighters ahead 3-2.
But Manny Pina led off the bottom of the inning with a single off Hunter.
A Jedd Gyorko double moved him to third and he would score on an Alex Bregman sacrifice fly to send to the 12th inning.
Kemp came through with another big hit, this time a single off Diekman which scored Leury Garcia, to make it 4-3.
But in the bottom of the 12th, Brock Holt singled with one out off Hunter and Andrew Toles followed with a walk.
A Manny Pina single loaded the bases before Gyorko hit into a force out that retired Holt at the plate.
But Cain followed with a sharp single to left, scoring Toles and Pina to win the game.