Are you wanting 2 games against the other 20 teams in the subleague with the other 60 or so games split among the 4 division opponents?
The 25 teams per subleague is an issue because an odd number means at least 1 team cannot be playing at any given time. Thus the 100 games with 4 games per week would not fit with 25 weeks because not all teams would be playing in 4 games per week.
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