The game isn't "locking" up. It's processing. I've had the same problem. Best thing to do is hit Alt-Tab and switch to whatever you want to do, and then come back in a bit. I've had no problems using this method. When I bring up OOTP5 sometimes it's a blank screen or something, only because it's working on something and isn't too concerned with refreshing it's graphics until it's done.
This happens with a lot of high end games, not just OOTP
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