How's this...
Babe Ruth retires with 301 Home runs, having been plagued by injury from 1924 on.
Joe D. only played 4 years before fracturing his knee.
Ted Williams is the career leader in damn near everything, with 677 HRs. Played from '39 to '63, League MVP 10 times.
Mantle is single season HR king with 63 in 1953.
Aaron is at 443 in 1968, but the injury bug looks to be striking.