Here's an interesting one to watch:
TWB Strikeouts Record
263 - David Wickersham (1934, CHN)
Frank Smith has 80 at the end of May in 39 starts, roughly a third of the way through the season. It's "only" pace for 240, and Frank has been so lights out that it's hard to imagine him pitching better. But he did take a major jump up in K/9 in May:
K/9 IP
5.30 - Apr
6.71 - May
If he keeps up the May rate, he looks to be in the 250-255 range. Still tough to reach, but it would be an interesting chase if he can get to September with a chance.
The ERA record remains Andrew Murphy's 1.18 in 1917, which was the season Murph broke his finger at the end of the season and missed the World Series... and we all know how that turned out.

Frank would need to stand on it with his 1.44 ERA to give that a run. I think he has it in him, but the horrendus Bums offense may be frustrating him.
John