Quote:
Originally Posted by RooneyTunes
Missions are based on your card collection while chemistry is based on your active roster. You don't complete missions with your active roster, so missions have zero to negligible impact on chemistry.
Your active roster is only 26 cards, while missions dip require you to collect more. For instance, you would get a massive chemistry boost for playing the Atlanta Braves 26 man roster, but that's not how you complete the Braves mission. The goal of league play is still to build the best roster possible. Chemistry will likely only have a significant impact on theme teams (teams that purposefully build their roster around a certain theme, like only Boston Red Sox players or only teammates of Roy Halladay), which don't expect to compete anyways.
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I have completed all the missions so far. Im sitting at 77% chemistry because those players in the missions all boost each other.