I do it, at the start. I trim the roster gradually as spring training goes along. I don't start any position players two days in a row (except right at the end, when I might have trimmed it to the point that I have to do that). I make sure all of them get a few starts. I use a six-man starting rotation and I prioritize rest for relievers.
I have failed to use a few pitchers, in some years, but it only happens if I'm close to 30 pitchers to begin with. If the breakdown is closer to 40-20 or even, probably, 35-25, everybody plays.
And I still lose guys to season-ending injuries, but I think I'd lose more if I played my first-tier guys more often.
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