There's no inherent reason it would be a bad thing
Specifically, it may matter if:
-your stadium favors right-handed hitters
-your division or league opponents have relatively more (or better) right-handed hitters
-your playoff opponents have relatively more (or better) right-handed hitters
But, of course, it may favor you if the opposites are true.
It also may favor you if stealing is emphasized in your league and your left-handed pitchers are better at holding runners
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