[marc5477]

A bit late to answer and it depends on your settings but I have found the following to be extremely effective in almost all instances:

Tip #1: Avoid any player over the age of 28 until round 15 or so.
Tip #2: Avoid fragile players like the plague until after round 30 or so
Tip #3: Avoid position player who cant play D! Dont underestimate D!!
Tip #4: Do not be afraid to take elite rookies as early as round 11 (earlier if their main stats are 50%+ developed)

Rounds 1-3 (prioritize durable players)

- Elite Starting Pitcher (1st)
- Elite slot 3 power hitter with high contact, avoid K, and power
- All-Star caliber Starting Pitcher (2nd)

Round 4-6 (prioritize durable players)

- Starting Pitcher (3rd)
- Extreme Home Run Cleanup guy - Max power, everything else secondary
- Lead off man with .300 BA, .400 OBP and good speed/stealing (priority to stealing ability)

Round 7-10 (normal injury rating is ok from here on)

- Starting pitcher (4th)
- Slot 2 hitter with high contact, high avoid K & good eye
- Elite Closer (they should still be available at this stage)
- Slot 5 home run hitter with priority to power

Round 11-20

At this point your core team is built. The AI is probably still filling slots with mediocre stock so this is your change to start planning for the future. Go after the best prospects, ones that are almost fully developed but not yet. At some point however, you want to pick up at least the following.

- Starting Pitcher (5th)
- Starting Pitcher (6th, acts as long relief) - Yes this is very important
- Setup reliever (backup closer)
- 5 or so highly rated prospects which are at least 50% developed
- 1 or 2 good defensive starters with ok contact and high eye if possible

From here its up to you. That mix generally serves me very well.