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I think part of it depends on your computer. Players develop while sitting on your reserve roster but the game doesn't sim any games for them. If you use minors, then there are games to be simmed and you have stats etc to go along with that development.
Are you worried about how quickly you can sim games? Then this is a consideration.
I haven't looked at it, but i'm sure the game has the African countries with city populations for cities in those countries. It would use that data to set up your leagues. It will use the bigger, major cities for your major leagues and use the smaller ones for your minors. You tell the game what country to source the league from.
You can set this up a lot of different ways. You could decide the teams yourself and do it manually. You could just take what the game gives you when you first add the teams to your league.
The possibilities with regards to setting this up are almost limitless. You just have to know what you want. Knowing what you want comes in part from playing the game and seeing what you can do with it.
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