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Short answer: Yes to all of that. If you handle those things like you see MLB teams handle those things you will get better, more realistic results.
Long Answer: As with everything in baseball its really tough to quantify the effects of those things and OOTP is a simulation. It ultimately gets most things rights but its trying to emulate what may happen in real lfe and it may not be 100% accurate. Best to feel things out for what the proper balances maybe in OOTP vs what actaully happens in real life. But in general concepts are the same. Players fatigue, wear, get rust and need to balance playing time for rest and sharpness. Platooning and splits do matter and have effects, etc.
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