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Here's what I do in my 24-team league with 30-round draft.
ML 25
AAA 25
AA 26
A 27
SA 28
R Unlimited
The AI tends to carry to carry 50-60 players. As long as you turn on favor talent over ability for your league's minor league depth charts you will not have any problems.
Also, I have been manipulating the ML service time and maximum ages for my R-AA leagues.
Essentially, you can change the settings to whatever interests you most, within reason. My biggest suggestion to you as you learn what all of these various setting do is to practice them on test-leagues.
Keep your keeper-league safe.
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