I always turn off the DH in my solo leagues. I love finding pitchers that can hit decently as well as pitch. OOTP does generate some of them now. It opens up some interesting oddball strategies that you don't see in MLB, like starting a reliever who can hit and letting him get one plate appearance. You could also have a defensive specialist start the game if the pitcher can field and swap them before the defensive guy hits and bring in a fresh pitcher.
I enjoy experimenting with odd strategies and leagues, in case that isn't obvious.