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My first thought is that, with only three "true" starting pitchers on your staff, if your "opening pitcher" gets lit up you're kind of screwed for the next couple of days. That and general wear and tear with relievers getting a lot more innings means you'd eventually need to push for 13-14 man pitching staffs and probably larger rosters overall.
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"Sometimes, this is like going to a grocery store. You’ve got a list until you get to the check-out stand. And then you start reading People magazine, and all this other [stuff] ends up in the basket."
-Sandy Alderson on the MLB offseason
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