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To add to pstrickert's post, OOTP does not have a database for disabled list transactions. So, while the game can use real lineups and transactions, it does not know when players were placed on the DL, and it may not have all transactions for minor league promotions, demotions, or rehab assignments.
So all the game can do is start each game with the real lineups, assuming that you've chosen the settings correctly from the beginning, and thereafter you may see deviations. The primary instance is players coming into the game as substitutes or pinch hitters when they may have been on the DL in real life.
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