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If you create the league using real transactions and lineups, trading should be turned off by default.....also there are no roster limits....all players that appeared that year are on the active roster....injuries are also turned off by default (if you want the real lineups, players can't be hurt on days they actually played)......the game won't follow real injuries, but players won't be in the lineup on days they were actually injured (however, they can and will enter the game as substitutes).....there is no setting to stop the sim if a real transaction cannot be accomplished, however the list of all real transactions for the whole year is available to view at any time.....you cannot edit the transactions to include or exclude any......
The game will allow you to turn trading on while playing with real lineups and transactions (why, I don't know), however this will effectively end the use of real lineups and transactions that cannot be accomplished due to players not being on there real life teams, will be skipped.......and you can trade Frank Robinson to the 1962 Mets, but he will only pinch hit as long as the player who actually played his position that day is on the roster......all in all there is really no reason to seriously consider mixing the two formats.....
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