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Well, as I am sure you know, there is no pat answer to that question.
Normally I use my two best relief pitchers as my setup men. The idea being this is going to be the pitchers you send in in the 8th inning when your starter just gave up a base hit and a walk and you need somebody to get you out of the jam.
For the mop up pitcher I usually pick a middle reliever who has pretty high stamina but not much else. The idea being that if you are 8 runs up or 8 runs down, you can use him to eat up some innings and protect your bullpen.
The spot starter is kind of the same reasoning for me. Typically he will be my 6th starter. But I don't use that slot that often except for when you expand to the 40 man roster.
Like I say, this is just my reasoning, your mileage my vary.
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