I use close the real MLB set-up but with fictional players.
I will go to a 15 and 15 format by moving Houston to the AL West.
I will put in a $100m cap.
DH in both leagues.
Rotating interleague schedule similiar to the NFL's. The schedules are found here.
http://www.ootpdevelopments.com/boar...-schedule.html
Then I will take over the Detroit Tigers as GM. I set up line-ups and pitching staff then hit quick play one game at a time and check out every box score and do my GM thin making adjustments to the roster and line-ups/pitching staffs as needed.