Well, you're always going to have to transfer your league files to the computer you're going to play on. Depending on how often you switch would dictate the changes in your league file. I first started switching pretty regularly, and now play almost exclusively on my laptop. But...point being, I zip up my whole league file, update it occasionally if I'm planning on using the desktop in the near future, then just transfer it via flash drive to the saved games folder, letting it overwrite/update each time.
An altenative is using the shared folders in a home network. Then you can grab the zip file off of the 'home' folder and use it on your remote unit. That actually takes a little longer to do, but it avoids the mobile hardware.
The bare necessities are the .dat files. However for the complete experience do the zip up the whole league file. So, the answer's no?
