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When I was just getting into OOTP, I simmed a complete MLB season (including full minors) and had tons of problems with injuries down at the farm, because I didn't have any ghost players and some of my affiliates didn't have backups at certain positions. Starters would be forced into playing their positions every day, got injured often and their development was obviously affected.
So, in addition to the great points made by bluenoser, I'd only like to say that ghost players not only don't interfere with minor leaguers performance/development in the very least, but actually help keep them healthy, fresh and productive. Definitely a much better option, IMO.
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