I set my lineups a couple of times throughout ST. I might slot in a young starter 2-3 times, but I sim 'em all and everybody does fine.
I don't think there is a "best" way to do this. 
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Cheers
RichW
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“Conservatism consists of exactly one proposition …There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.” Frank Wilhoit
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