Here's a couple things I do that give me some results I like.
My best reliever gets placed in the closer role and as MR #3 or #4 (depending on bullpen size). This leads to him pitching the most games, the most innings (if decent stamina), and ends up with the most saves.
My second best reliever gets the #1 MR spot.
My best reliever with terrible stamina typically gets the setup #1 spot.
If I only have one lefty, they typically get placed in one of the MR spots and the setup #2 spot.
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