Note for other responders: This is an OOTP3 question.
First of all if you are close to the minimum specs and/or running background apps then it's possible that the game will actually proceed if you give it more time (even if it says "not responding"). The Rolen rosters add a lot of players to the games DB which slows down performance, hence why your other leagues may have worked fine and this one may not. Also, there were some issues with some of the early versions of that roster set, is it possible you used an early version?
Other than that I'd suggest you do a forum search and you might see some related answers that may help.
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