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1) I suggest not starting as a manager in the minor leagues. The game is flawed from this aspect - your big league club will move guys on and off your team without warning constantly. I don't know if OOTPX still does this, but if I remember correctly the game would reset your lineups/pitching staffs each time it made a roster move, too.
2/3) Just jump in with the default settings. Or, to make things a bit simpler, go into your Game Setup and turn off injuries, waivers, the Rule V Draft, option years and other similar things. Makes it a little simpler to learn the ropes of the base game mechanics without being overwhelmed with possibilities and things to pay attention to.
Spend some time looking over the preferences, setup and option tabs. Just see what you can/can't turn on and off and what some of the deeper game settings are. Don't worry about having to mess with them, just read them and get a feel for it.
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