This might be impossible, but I thought I'd post this to see if it is:
256 teams
2 leagues, 16 divisions each, 8 teams per division
Schedule format:
Divisions are in pods of 4(1-4, 5-8, 9-12, 13-16)
Each team plays the 24 non-divisional teams in their own pod 3 times(3H or 3A)---thats 72 games; therefore you only play non-divisional games vs. teams in 3 specific divisions(example: Division 7 will play divisions 5, 6 and 8 only)
For the remaining 90 games, each team plays their 7 divisional rivals 12-13 times
No interleague
If anyone can pull this off, you are quite talented