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Even if you run the team, you cannot make substitutions in a game if that privilege is delegated to your AI manager. You can check that by clicking Options while in the game and looking at your teams Controls. Make sure you are selected, not the manager.
Even so, something should have happened: You should have gotten a warning that "You are not allowed to control this team." If you did not see that, then my next guess is that you are neither in control of the team nor acting as the commissioner, allowing you to make changes regardless of who runs the team.
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