I installed OOTP on a 500GB external hard drive (designate E

, but the game still saves all my leagues on the C drive, which is only 120 GB and will run out of space quickly.
I tried to change the save directory to the E drive, copied all the files to the designated folder, but the next time I started the game it crashed on loading and told me that it couldn't find the files. I had to do a full re-install. So I dealt with it saving to C for a while but, like I said, the hard drive is filling up, and I really would like to get it to save to my E drive.
Any help would be excellent, thank you in advance.