Curtis Cook's point about avoiding obsession over minute details is a good one.
Curtis, I had the same experience. I won't go into details (see, I've learned

), but suffice to say that at one point I was searching the Internet for data on Taiwan baseball stadiums as an example of going overboard, IMO. Realize that I was dealing with 368 teams and stadiums in my universe at the time.
Tullius, this would definitely be #2 on my list of potential problems, and you could still encounter it even with a smaller universe. This game allows for a massive amount of customization which may cross the boundary between fun and work if you let it.