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OK, take this with a grain of salt as I haven't tried this myself. But this might be the sort of case where an anti-virus program might really slow things down.
If the game is doing a lot of modifying of files, especially opening then closing then opening then closing, etc, the anti-virus software may step in each time and do a little check to make sure everything's kosher ... which in turn would really slow things down.
Again, take this with a grain of salt. I don't work here, I haven't loaded in a Lahman database, and I didn't even stay at a Holiday Inn Express last night.
But with some people saying its fast and some people saying its really slow, that might be a guess I might take.
A completely unrelated case where an anti-virus program does massively slow things down is disk de-fragmentation. I know from experience its several orders of magnitude slower with the anti-virus enabled than disabled. And its because the anti-virus software keeps jumping in and checking every change.
Attach all required disclaimers about why anti-virus is very important and why I don't shut them down lightly. But its something someone might think of trying ... after making sure they are either off-line or not doing any interactions with the internet while doing that test.
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