If I have one really dominant pitcher, and the rest of the staff is .500, then I have a legitimate shot at the pennant.
Example: One starter 27-5, leaves 130 other games.
Half of 130 = 65, plus 27 = 92 wins.
So, in my fictional leagues - I always have the very first pick, funny how it works out;

I get the very finest pitcher available.
After that, I look for the highest OBP guy, then the potentially highest OPS guy.
Then build around.
I only look at speed and defense if they are exceptionally good (or bad), as a factor.