[ifspuds]

Depends on how many bells and whistles you enable. If it's a no-financials league, it's much easier. You have to process all the roster movement, but you don't have to worry about free agency, extensions and so on. Waivers and 40-man rosters are very difficult to run effectively if your owners don't have the game to do their own micromanaging.

Personally, I find it exhausting. I ran a league where 3 or 4 of my 15 other owners had the game and the rest didn't, and I was burned out after 2.5 seasons. So consider how much time and effort you're willing to put into doing a lot of the work for your owners before you take it on.

Best of luck to you!